| 14/08/2021 | 18:30 | Norwich City FC | 0 | 3 | Liverpool FC |
| 21/08/2021 | 13:30 | Liverpool FC | 2 | 0 | Burnley FC |
| 28/08/2021 | 18:30 | Liverpool FC | 1 | 1 | Chelsea FC |
| 12/09/2021 | 17:30 | Leeds United FC | 0 | 3 | Liverpool FC |
| 15/09/2021 | 21:00 | Liverpool FC | 3 | 2 | AC Milan |
| 18/09/2021 | 16:00 | Liverpool FC | 3 | 0 | Crystal Palace FC |
| 25/09/2021 | 18:30 | Brentford FC | 3 | 3 | Liverpool FC |
| 28/09/2021 | 21:00 | FC Porto | 1 | 5 | Liverpool FC |
| 03/10/2021 | 17:30 | Liverpool FC | 2 | 2 | Manchester City FC |
| 16/10/2021 | 13:30 | Watford FC | 0 | 5 | Liverpool FC |
| 19/10/2021 | 21:00 | Club Atlético de Madrid | 2 | 3 | Liverpool FC |
| 24/10/2021 | 17:30 | Manchester United FC | | | Liverpool FC |
| 30/10/2021 | 16:00 | Liverpool FC | | | Brighton & Hove Albion FC |
| 03/11/2021 | 22:00 | Liverpool FC | | | Club Atlético de Madrid |
| 07/11/2021 | 18:30 | West Ham United FC | | | Liverpool FC |
| 20/11/2021 | 19:30 | Liverpool FC | | | Arsenal FC |
| 24/11/2021 | 22:00 | Liverpool FC | | | FC Porto |
| 27/11/2021 | 17:00 | Liverpool FC | | | Southampton FC |
| 01/12/2021 | 22:15 | Everton FC | | | Liverpool FC |
| 04/12/2021 | 17:00 | Wolverhampton Wanderers FC | | | Liverpool FC |
| 07/12/2021 | 22:00 | AC Milan | | | Liverpool FC |
| 11/12/2021 | 17:00 | Liverpool FC | | | Aston Villa FC |
| 16/12/2021 | 22:00 | Liverpool FC | | | Newcastle United FC |
| 19/12/2021 | 18:30 | Tottenham Hotspur FC | | | Liverpool FC |
| 26/12/2021 | 14:30 | Liverpool FC | | | Leeds United FC |
| 28/12/2021 | 22:00 | Leicester City FC | | | Liverpool FC |
| 02/01/2022 | 18:30 | Chelsea FC | | | Liverpool FC |
| 15/01/2022 | 17:00 | Liverpool FC | | | Brentford FC |
| 22/01/2022 | 17:00 | Crystal Palace FC | | | Liverpool FC |
| 09/02/2022 | 22:00 | Liverpool FC | | | Leicester City FC |
| 12/02/2022 | 17:00 | Burnley FC | | | Liverpool FC |
| 19/02/2022 | 17:00 | Liverpool FC | | | Norwich City FC |
| 26/02/2022 | 17:00 | Arsenal FC | | | Liverpool FC |
| 05/03/2022 | 17:00 | Liverpool FC | | | West Ham United FC |
| 12/03/2022 | 17:00 | Brighton & Hove Albion FC | | | Liverpool FC |
| 19/03/2022 | 17:00 | Liverpool FC | | | Manchester United FC |
| 02/04/2022 | 16:00 | Liverpool FC | | | Watford FC |
| 09/04/2022 | 16:00 | Manchester City FC | | | Liverpool FC |
| 16/04/2022 | 16:00 | Aston Villa FC | | | Liverpool FC |
| 23/04/2022 | 16:00 | Liverpool FC | | | Everton FC |
| 30/04/2022 | 16:00 | Newcastle United FC | | | Liverpool FC |
| 07/05/2022 | 16:00 | Liverpool FC | | | Tottenham Hotspur FC |
| 15/05/2022 | 16:00 | Southampton FC | | | Liverpool FC |
| 22/05/2022 | 17:00 | Liverpool FC | | | Wolverhampton Wanderers FC |