| 06/08/2022 | 13:30 | Fulham FC | 2 | 2 | Liverpool FC |
| 15/08/2022 | 21:00 | Liverpool FC | 1 | 1 | Crystal Palace FC |
| 22/08/2022 | 21:00 | Manchester United FC | 2 | 1 | Liverpool FC |
| 27/08/2022 | 16:00 | Liverpool FC | 9 | 0 | AFC Bournemouth |
| 31/08/2022 | 21:00 | Liverpool FC | 2 | 1 | Newcastle United FC |
| 03/09/2022 | 13:30 | Everton FC | 0 | 0 | Liverpool FC |
| 07/09/2022 | 21:00 | SSC Napoli | 4 | 1 | Liverpool FC |
| 10/09/2022 | 16:00 | Liverpool FC | Wolverhampton Wanderers FC | ||
| 13/09/2022 | 21:00 | Liverpool FC | 2 | 1 | AFC Ajax |
| 18/09/2022 | 17:30 | Chelsea FC | Liverpool FC | ||
| 01/10/2022 | 16:00 | Liverpool FC | 3 | 3 | Brighton & Hove Albion FC |
| 04/10/2022 | 21:00 | Liverpool FC | 2 | 0 | Rangers FC |
| 09/10/2022 | 17:30 | Arsenal FC | 3 | 2 | Liverpool FC |
| 12/10/2022 | 21:00 | Rangers FC | 1 | 7 | Liverpool FC |
| 16/10/2022 | 17:30 | Liverpool FC | 1 | 0 | Manchester City FC |
| 19/10/2022 | 20:30 | Liverpool FC | 1 | 0 | West Ham United FC |
| 22/10/2022 | 13:30 | Nottingham Forest FC | 1 | 0 | Liverpool FC |
| 26/10/2022 | 21:00 | AFC Ajax | 0 | 3 | Liverpool FC |
| 29/10/2022 | 20:45 | Liverpool FC | 1 | 2 | Leeds United FC |
| 01/11/2022 | 22:00 | Liverpool FC | 2 | 0 | SSC Napoli |
| 06/11/2022 | 18:30 | Tottenham Hotspur FC | 1 | 2 | Liverpool FC |
| 12/11/2022 | 17:00 | Liverpool FC | 3 | 1 | Southampton FC |
| 26/12/2022 | 19:30 | Aston Villa FC | 1 | 3 | Liverpool FC |
| 30/12/2022 | 22:00 | Liverpool FC | 2 | 1 | Leicester City FC |
| 02/01/2023 | 19:30 | Brentford FC | 3 | 1 | Liverpool FC |
| 14/01/2023 | 17:00 | Brighton & Hove Albion FC | 3 | 0 | Liverpool FC |
| 21/01/2023 | 14:30 | Liverpool FC | 0 | 0 | Chelsea FC |
| 04/02/2023 | 17:00 | Wolverhampton Wanderers FC | Liverpool FC | ||
| 13/02/2023 | 22:00 | Liverpool FC | Everton FC | ||
| 18/02/2023 | 19:30 | Newcastle United FC | Liverpool FC | ||
| 21/02/2023 | 22:00 | Liverpool FC | Real Madrid CF | ||
| 25/02/2023 | 21:45 | Crystal Palace FC | Liverpool FC | ||
| 05/03/2023 | 18:30 | Liverpool FC | Manchester United FC | ||
| 11/03/2023 | 14:30 | AFC Bournemouth | Liverpool FC | ||
| 15/03/2023 | 22:00 | Real Madrid CF | Liverpool FC | ||
| 18/03/2023 | 17:00 | Liverpool FC | Fulham FC | ||
| 01/04/2023 | 16:00 | Manchester City FC | Liverpool FC | ||
| 08/04/2023 | 16:00 | Liverpool FC | Arsenal FC | ||
| 15/04/2023 | 16:00 | Leeds United FC | Liverpool FC | ||
| 22/04/2023 | 16:00 | Liverpool FC | Nottingham Forest FC | ||
| 25/04/2023 | 20:45 | West Ham United FC | Liverpool FC | ||
| 29/04/2023 | 16:00 | Liverpool FC | Tottenham Hotspur FC | ||
| 06/05/2023 | 16:00 | Liverpool FC | Brentford FC | ||
| 13/05/2023 | 16:00 | Leicester City FC | Liverpool FC | ||
| 20/05/2023 | 16:00 | Liverpool FC | Aston Villa FC | ||
| 28/05/2023 | 17:00 | Southampton FC | Liverpool FC |